欧阳小琨（Ouyang XK），江西吉安人，教授、博士生导师。2007年毕业于浙江大学获工学博士学位，主要从事纳米药物、生物材料和海洋生物资源综合利用等领域的研究。主持国家重点研发项目一项、主持完成国家基金面上项目2项，承担省部级科研项目10余项，以第一作者或通讯作者发表SCI期刊论文100余篇，SCI被引6400余次，H指数48，获授权发明专利40余项，以第一完成人获中国商业联合会科技进步奖一等奖2项、二等奖1项、三等奖2项，获中国轻工业联合会科技进步奖三等奖一项，舟山市科技进步奖二等奖一项，获浙江省科技进步奖一等奖一项(排名第五)、三等奖一项(排名第二)，入选全球前2%顶尖科学家榜单(World's Top 2% Scientists 2020、2021、2022、2023、2024)。2010年入选舟山市111人才工程第二层次培养对象、2013年入选浙江省高校中青年学科带头人。
研究方向：1. 海洋生物资源功能化利用；2. 生物材料；3. 纳米药物。
Email: xkouyang @zhwav.org； [email protected]
主要学习工作经历
2004.07-2007.06，浙江大学，化学工程，博士
2007.07-至今，中文av
，历任讲师、副教授、教授
学术兼职
Advanced Functional Materials、Bioactive Materials、Chemical Engineering Journal、Carbohydrate Polymers、ACS Applied Materials & Interfaces、Acta Biomaterialia、Materials Today Chemistry 、Biomaterials Advances、Materials Today Bio等三十余个国际期刊的审稿专家，担任东华理工大学学报(自然科学版)编委。是国家自然科学基金网络评审专家、浙江省、湖南省、山东省、河北省、广东省、河南省等省份科技评审专家。
获奖
2023，贻贝全产业链加工关键技术及系列产品开发与产业化，浙江省科技进步奖三等奖（3/7）
2017，海洋风味水产品中有害物质分析与质量控制关键技术研究, 中国轻工业联合会科技进步三等奖(1/6)
2016，海产品危害因子分析与质量控制关键技术构建与应用, 浙江省科技进步奖三等奖(2/6)
2016，水产品中手性药物残留检测技术体系构建与应用，中国商业联合会科技进步一等奖(1/5)
2015，海产品有害物质分析与质量控制关键技术研究, 中国商业联合会科技进步二等奖(1/8)
2009，雷公藤有效成分的提取分离及质量控制技术，浙江省科技进步奖一等奖(5/13)
代表性项目
1. 国家重点研发计划政府间国际科技创新合作项目，异质结功能化小球藻纳米胶囊调控肿瘤微环境与肿瘤光动力/免疫协同治疗研究、2023/04-2026/03、主持。
2. 国家自然科学基金面上项目，以功能离子液体微胶囊为介质分离雷公藤生物碱的应用基础研究、2010/01-2012/12，主持。
代表性论文 (*标记为通讯作者)
[18] Liying Ge, Junhong Ling, Guozhou Cao, Xiao–kun Ouyang*, Nan Wang*. Nanozyme doped chitosan hydrogel driven by glucose oxidase for dual regulation of ROS homeostasis and macrophage reprogramming in diabetic wound healing. Carbohydrate Polymers, 2026, 373:124534. (IF 12.5)
[17]Jiajing He, Tianlu Dong, Fanyan Zhou, A. M. Omer, Xiao–kun Ouyang*, Lin Mei*, Nan Wang*. Chitosan-based glucose-responsive hydrogel with spatiotemporally controlled bactericidal release for diabetic wound regeneration via multimodal therapy. Carbohydrate Polymers, 2026,373: 124446. (IF 12.5)
[16]Wenxin Fu, Junhong Ling, A. M. Omer, Xiao–kun Ouyang*, Lin Mei*, Nan Wang*. Biohybrid microneedle delivering engineered probiotics for synergistic tumor gas/photothermal-immunotherapy. Chemical Engineering Journal, 2025,522: 168014. (IF:13.2)
[15]Yanfei Zhu, Nan Wang, Hanjie Zhang, Junhong Ling, A. M. Omer, Guocai Yang, Xiao–kun Ouyang*, Lin Mei*. Copper peroxide-triggered reactive nitrogen effectively enhanced synergistic chemodynamic-immunotherapy. Journal of Colloid and Interface Science, 2025, 699: 138301. (IF 9.7).
[14] Zhen Liu, Wei Hu, Yingying Cai, Nan Wang, A. M. Omar, Junhong Ling*, Lin Mei*, Xiao–kun Ouyang*. Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy. Journal of Colloid and Interface Science, 2025, 690: 137332. (IF 9.7).
[13] Shuhan Zhao, Wei Zhao, Nan Wang, Junhong Ling*, Xiao–kun Ouyang*. A sustained H2S-releasing nanocellulose-based hydrogel with anti-inflammatory and antibacterial properties for promoting infected wound healing. Carbohydrate Polymers, 2025,355: 123424. (IF 12.5)
[12] Z Liu, JH Ling*, N Wang*, XK Ouyang*, Redox homeostasis disruptors enhanced cuproptosis effect for synergistic photothermal/chemodynamic therapy, Journal of Colloid and Interface Science, 2025, 678: 1060-1074. (IF 9.4).
[11]W Hu, LL Yang, HT Liang, DG Sun, XK Ouyang*, Nan Wang*, GC Yang, Disulfiram-loaded CuO2 nanocarriers for enhanced synergistic chemodynamic/chemotherapy, Journal of Colloid and Interface Science, 2024, 674:9-18. (IF 9.4).
[10] SH Zhao, Junhong Ling*, Nan Wang*, XK Ouyang*, Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing, Chemical Engineering Journal, 2024, 497:154517. (IF 13.3)
[9] XH Wang, MY Ren, N Wang*, JH Ling, YH He, SY Huang, XK Ouyang*, Zeolitic imidazolate framework-8@polydopamine decorated carboxylated chitosan hydrogel with photocatalytic and photothermal antibacterial activity for infected wound healing, Journal of Colloid and Interface Science, 2024, 675:1040-1051. (IF 9.4).
[8]BJ Cheng, RL Wang, XH Wang, N Wang*, XK Ouyang*, Heterojunction functionalized sodium alginate/carboxylated cellulose nanocrystals film enhancing sterilization performance for wound healing, Carbohydrate Polymers, 2024, 345: 122550. (IF 10.7)
[7] Liang JH, Ling JH, Sun DG, Wu GH, Ouyang XK(*), Wang N (*), Yang GC(*), Dextran-based antibacterial hydrogel dressings for accelerating infected wound healing by reducing inflammation levels, Advanced Healthcare Materials, 2024: 202400494. (IF 10)
[6] Zhu YF, Wang N, Ling JH, Yang LL, Ouyang XK(*), Omer AM, Yang GC(*). In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy, Journal of colloid and interface science, 2024, 660: 637-646. (IF 9.9)
[5]Liang JH, Ling JH, Zhang X, Ouyang XK(*), Omer AM, Yang GC(*).pH/glutathione dual-responsive copper sulfide-coated organic mesoporous silica for synergistic chemo-photothermal therapy, Journal of colloid and interface science, 2024, 657:1-14. (IF 9.9)
[4]Zhu YF, Ling JH, Xu XY, Ouyang XK(*), Wang N(*). Redox and pH dual sensitive carboxymethyl chitosan functionalized polydopamine nanoparticles loaded with doxorubicin for tumor chemo-photothermal therapy, International Journal of Biological Macromolecules, 2023, 240: 124488. (IF 8.025)
[3] Chen J, Zhao LJ, Ling JH, Yang LY, Ouyang XK(*), A quaternized chitosan and carboxylated cellulose nanofiber-based sponge with a microchannel structure for rapid hemostasis and wound healing, International Journal of Biological Macromolecules, 2023, 233: 123631. (IF 8.025)
[2] Liu CN, Ling JH(*), Yang LY, Ouyang XK(*), Wang N(*). Chitosan-based carbon nitride-polydopamine‑silver composite dressing with antibacterial properties for wound healing, Carbohydrate Polymers, 2023, 303: 120436. (IF 10.723)
[1] Ouyang XK(*), Zhao LJ, Jiang FY, Ling JH(*),Yang LY, Wang N(*). Cellulose nanocrystal/calcium alginate-based porous microsphere for rapid hemostasis and wound healing. Carbohydrate Polymers, 2022, 293:119688.(IF 10.723 )
代表性专利
(15) 张一鸣，欧阳小琨，梁建浩，一种用于组织创面修复的海绵复合物及其制备方法，授权发明专利：202210713997X
(14) 项昕晨，欧阳小琨，凌俊红，韩榕，范丽红,一种传递姜黄素的岩藻多糖-介孔二氧化硅复合纳米粒子，授权发明专利：2021111797050
(13) 骆君怡，欧阳小琨，章宏，一种递送姜黄素的大豆分离蛋白-卡拉胶纳米复合物，授权发明专利：2021 101085083
(12)黄莉莉, 欧阳小琨, 章宏, 一种共递送岩藻黄素和槲皮素的高粱醇溶蛋白-岩藻多糖复合物, 授权发明专利：2021101093126
(11) 韩榕，欧阳小琨，凌俊红，范丽红，一种递送岩藻黄素的褐藻寡糖-介孔二氧化硅纳米复合物，授权发明专利：202111179753X
(10) 欧阳小琨，赵丽娟，凌俊红，蒋方园，杨立业，一种基于海藻酸钠、纳晶纤维素的抗菌止血多孔微球，授权发明专利：2021 110610583
(9) 马瑞，欧阳小琨，王松艳，黄依如，一种递送姜黄素的zein-AOS复合纳米颗粒及其制备方法，授权发明专利：2021 107545288
(8) 叶文鹏，欧阳小琨，王南，赵丽娟，凌俊红，一种用于组织创伤愈合修复的纤维素壳聚糖单宁酸铜复合凝胶海绵及其制备方法, 授权发明专利：ZL2021113761744
(7) 韩榕，欧阳小琨，黄依如，范丽红，一种褐藻寡糖修饰的氨基化介孔二氧化硅纳米颗粒,授权发明专利：ZL202111060301X
(6)欧阳小琨，梁建浩，凌俊红，卢雨清，杨立业，一种阿霉素偶联壳寡糖的纳米粒子， 授权发明专利：ZL2021110898603
(5)欧阳小琨，卢雨清，杨立业，范丽红，一种利用南极磷虾壳制备氨基壳聚糖的方法，授权发明专利：ZL2019109600259
(4)欧阳小琨，卢雨清，杨立业，范丽红，一种南极磷虾小分子肽的制备方法，授权发明专利：ZL 2019108714623
(3)欧阳小琨，卢雨清，杨立业，范丽红，一种基于南极磷虾壳的止血材料的制备方法及其应用，授权发明专利：ZL 2019109600329
(2) 欧阳小琨，杨立业，郁迪，一种吸附南极磷虾油中砷的方法，授权发明专利，ZL 2017108133999
(1) 欧阳小琨，马剑茵，一种传递5-氟尿嘧啶微球的制备方法，授权发明专利，ZL 201710859517X
